2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0832S
    L-Histidine-15N3 1217456-12-6 98%
    L-Histidine-15N3 is the 15N-labeled L-Histidine. L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
    L-Histidine-15N3
  • HY-N0837R
    Veratramine (Standard) 60-70-8
    Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine (HY-N0837). This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT)-related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy.
    Veratramine (Standard)
  • HY-N0839R
    Quillaic acid (Standard) 631-01-6
    Quillaic acid (Standard) is the analytical standard of Quillaic acid. This product is intended for research and analytical applications. Quillaic acid (Quillaja sapogenin)It is an anti-gastric cancer and anti-proliferation agent that can promote apoptosis of cancer cells. (apoptosis). Quillaic acidAlso has analgesic and local anti-inflammatory activity[1][2][3][4].
    Quillaic acid (Standard)
  • HY-N0894A
    (3R,5R)-Octahydrocurcumin 408324-14-1 98%
    (3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2.
    (3R,5R)-Octahydrocurcumin
  • HY-N0909R
    Notoginsenoside R2 (Standard) 80418-25-3
    Notoginsenoside R2 (Standard) is the analytical standard of Notoginsenoside R2. This product is intended for research and analytical applications.
    Notoginsenoside R2 (Standard)
  • HY-N0923R
    Corydaline (Standard) 518-69-4
    Corydaline (Standard) is the analytical standard of Corydaline. This product is intended for research and analytical applications. Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
    Corydaline (Standard)
  • HY-N0925R
    Tetrahydroberberine (Standard) 522-97-4
    Tetrahydroberberine (Standard) is the analytical standard of Tetrahydroberberine. This product is intended for research and analytical applications. Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.
    Tetrahydroberberine (Standard)
  • HY-N0931R
    Santacruzamate A (Standard) 1477949-42-0
    Santacruzamate A (Standard) is the analytical standard of Santacruzamate A. This product is intended for research and analytical applications. Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research[1][2].
    Santacruzamate A (Standard)
  • HY-N10060
    Millmerranone A 98%
    Millmerranone A shows the acetylcholinesterase inhibitory property.
    Millmerranone A
  • HY-N10080
    Paspalinine 63722-91-8 98%
    Paspalinine is a tremorgenic metabolite that can be found in Aspergillus flavus.
    Paspalinine
  • HY-N10119
    Ganoderterpene A 2682180-85-2 98%
    Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells.
    Ganoderterpene A
  • HY-N10274
    Herpotrichone B 2411834-18-7 98%
    Herpotrichone B shows potent anti-neuroinflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells with the half maximal inhibitory concentration (IC50) value of 0.11 μM.
    Herpotrichone B
  • HY-N10277
    Inubritannolide A 98%
    Inubritannolide A displays slight strong neuroprotective potency against different types of neuronal cells mediated by various inducers including H2O2, 6-hydroxydopamine (6-OHDA), and lipopolysaccharide (LPS).
    Inubritannolide A
  • HY-N10283
    Neoechinulin C 55179-54-9 98%
    Neoechinulin C, an echinulin-related indolediketopiperazine alkaloid, protects the neuronal cells against paraquat-induced damage in a Parkinson’s disease model.
    Neoechinulin C
  • HY-N10306
    Sycosterol A 98%
    Sycosterol A is a sterol-based α-synuclein (α-syn) inhibitor that targets α-synuclein aggregates and inhibits α-synuclein aggregation. Sycosterol A can be used in the study of anti-neurodegenerative diseases.
    Sycosterol A
  • HY-N10368
    Shinjulactone M 103630-27-9 98%
    Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma.
    Shinjulactone M
  • HY-N10384
    AChE-IN-17 460345-17-9 98%
    AChE-IN-17 (compound 1) is a potent AChE inhibitor with an IC50 value of 28.98 μM. AChE-IN-17 can significantly prevent H2O2-induced PC12 cell death, exhibiting excellent neuroprotective effect. AChE-IN-17 can be used for researching neurodegenerative diseases (NDs).
    AChE-IN-17
  • HY-N10408
    Tripchlorolide 132368-08-2 98%
    Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease.
    Tripchlorolide
  • HY-N10425
    2-Hydroxyalbrassitriol 1176586-98-3 98%
    2-Hydroxyalbrassitriol (Compound 6) is an AChE inhibitor with an IC50 of 35.97 μM.
    2-Hydroxyalbrassitriol
  • HY-N10429
    Geissoschizoline 18397-07-4 98%
    Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent.
    Geissoschizoline
Cat. No. Product Name / Synonyms Application Reactivity